Nature Communications (Dec 2019)

Biointerfacial self-assembly generates lipid membrane coated bacteria for enhanced oral delivery and treatment

  • Zhenping Cao,
  • Xinyue Wang,
  • Yan Pang,
  • Shanshan Cheng,
  • Jinyao Liu

DOI
https://doi.org/10.1038/s41467-019-13727-9
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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Oral microbiota delivery is an approach to treat and prevent disease but suffers from low retention and bioavailability. Here the authors report on a lipid coating to protect against environmental assault maintaining viability and bioactivity of the bacteria and demonstrate effective application in a colitis model.