A nitric oxide-releasing prodrug promotes apoptosis in human renal carcinoma cells: Involvement of reactive oxygen species

Xie Jindong; Chen Lieqian; Huang Dongqiang; Yue Weiwei; Chen Jingyu; Liu Chunxiao

doi:10.1515/chem-2020-0075

Open Chemistry (May 2021)

A nitric oxide-releasing prodrug promotes apoptosis in human renal carcinoma cells: Involvement of reactive oxygen species

Xie Jindong,
Chen Lieqian,
Huang Dongqiang,
Yue Weiwei,
Chen Jingyu,
Liu Chunxiao

Affiliations

Xie Jindong: Department of Urology, Zhujiang Hospital, Southern Medical University, No. 253, Industrial Road, Guangzhou, 510282, Guangdong, China
Chen Lieqian: Department of Urology, The First Hospital of Huizhou, No. 20, Sanxin Road, Huizhou, 516000, Guangdong, China
Huang Dongqiang: Department of Urology, The First Hospital of Huizhou, No. 20, Sanxin Road, Huizhou, 516000, Guangdong, China
Yue Weiwei: Department of Urology, The First Hospital of Huizhou, No. 20, Sanxin Road, Huizhou, 516000, Guangdong, China
Chen Jingyu: Department of Urology, The First Hospital of Huizhou, No. 20, Sanxin Road, Huizhou, 516000, Guangdong, China
Liu Chunxiao: Department of Urology, Zhujiang Hospital, Southern Medical University, No. 253, Industrial Road, Guangzhou, 510282, Guangdong, China

DOI: https://doi.org/10.1515/chem-2020-0075
Journal volume & issue: Vol. 19, no. 1
pp. 635 – 645

Abstract

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JS-K is a nitric oxide (NO)-releasing prodrug of the O2-arylated diazeniumdiolate group that shows pronounced cytotoxicity and antitumor properties in numerous cancer models, including in vitro as well as in vivo. Reactive oxygen species (ROS) induce carcinogenesis by altering the redox status, causing increment in vulnerability to oxidative stress.

Published in Open Chemistry

ISSN: 2391-5420 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Science: Chemistry
Website: https://www.degruyter.com/journal/key/CHEM/html

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