A case of pancreatitis, panniculitis and polyarthritis syndrome: Elucidating the pathophysiologic mechanisms of a rare condition

Ines Loverdos; Marc C. Swan; Shant Shekherdimian; Abdulrahman A. Al-Rasheed; Rayfel Schneider; Joel S. Fish; Bo-Yee Ngan; Khosrow Adeli; Mark E. Lowe; Vijay P. Singh; Wednesday Marie A. Sevilla; Jacob C. Langer; Tanja Gonska

doi:10.1016/j.epsc.2015.03.014

Journal of Pediatric Surgery Case Reports (May 2015)

A case of pancreatitis, panniculitis and polyarthritis syndrome: Elucidating the pathophysiologic mechanisms of a rare condition

Ines Loverdos,
Marc C. Swan,
Shant Shekherdimian,
Abdulrahman A. Al-Rasheed,
Rayfel Schneider,
Joel S. Fish,
Bo-Yee Ngan,
Khosrow Adeli,
Mark E. Lowe,
Vijay P. Singh,
Wednesday Marie A. Sevilla,
Jacob C. Langer,
Tanja Gonska

Affiliations

Ines Loverdos: Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Marc C. Swan: Division of Plastic Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Shant Shekherdimian: Division of General and Thoracic Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Abdulrahman A. Al-Rasheed: Division of Rheumatology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Rayfel Schneider: Division of Rheumatology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Joel S. Fish: Division of Plastic Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Bo-Yee Ngan: Division of Pathology, Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Khosrow Adeli: Division of Clinical Biochemistry, Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Mark E. Lowe: Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Vijay P. Singh: Division of Gastroenterology, Mayo Clinic, Rochester, MN, USA
Wednesday Marie A. Sevilla: Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Jacob C. Langer: Division of General and Thoracic Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Tanja Gonska: Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada

DOI: https://doi.org/10.1016/j.epsc.2015.03.014
Journal volume & issue: Vol. 3, no. 5
pp. 223 – 226

Abstract

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Pancreatitis-Panniculitis-Polyarthritis (PPP) syndrome is rare and its physiopathology unclear. A 6-year old boy suffered of traumatic pancreatitis complicated by PPP syndrome. Extensive investigations demonstrated high levels of pancreatic lipase and fatty acids in the affected peripheral tissues. These findings support the sequence of peripheral lipolysis and fatty acid accumulation inducing tissue inflammation.

Published in Journal of Pediatric Surgery Case Reports

ISSN: 2213-5766 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Pediatrics; Medicine: Surgery
Website: https://www.journals.elsevier.com/journal-of-pediatric-surgery-case-reports/

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Abstract

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