Nontraditional Factors Influencing Cardiovascular Disease Risk: Correlation Among Framingham Risk Score, Body Composition Index, and Sleep‐Breathing Monitoring Index

Abstract

ABSTRACT To examine the correlation among body composition, sleep‐breathing indicators, and Framingham risk score (FRS) to identify and amplify nontraditional factors that influence the risk of CVD in males, A total of 195 male participants underwent examinations for body composition and sleep‐breathing monitoring. We compared the differences in individual factors across various FRS groups. We further conducted multiple linear regression analysis. A cutoff value of FRS ≥ 14 was utilized, and potential influencing factors were examined by logistic regression analysis. Statistical differences were observed in the levels of fasting blood glucose (FBG), CO2, serum ferritin, hemoglobin (HB), and ECT/TBW among the FRS tripartite groups. However, no significant differences were found in AHI and MSpO2. The multiple linear regression analysis revealed positive correlations between ECW/TBW and FBG with FRS (β = 0.324 and 0.324, p < 0.001), while HB and muscle/fat mass exhibited negative correlations with the score (β = −0.185 and − 0.169, p < 0.01). These five factors—ECW/TBW, FBG, HB, serum ferritin, and muscle/fat mass—collectively accounted for 28.6% of the variation in FRS. A higher ECW/TBW was significantly associated with FRS ≥ 14 (OR = 2.208, 95% CI: 1.503–3.244). Conversely, reduced levels of muscle/fat mass, HB, and basal metabolic rate (BMR) were significantly linked to moderate‐to‐high CVD risk (ORratio = 0.532, 95% CI: 0.284–0.996; ORHB = 0.961, 95% CI: 0.932–0.991; ORBMR = 0.997, 95% CI: 0.995–1.000). This study revealed correlations among ECW/TBW, HB, FBG, and muscle‐to‐fat mass ratio with the risk of CVD predicted using FRSs.

Keywords

• body composition
• cardiovascular disease
• ECW/TBW
• Framingham risk score
• sleep‐breathing monitoring