Frontiers in Pharmacology (Jul 2021)

Potential Mechanisms of Action of Chinese Patent Medicines for COVID-19: A Review

  • Zhi-Hua Yang,
  • Zhi-Hua Yang,
  • Bin Wang,
  • Qian Ma,
  • Qian Ma,
  • Lin Wang,
  • Lin Wang,
  • Ya-Xin Lin,
  • Hai-Feng Yan,
  • Hai-Feng Yan,
  • Zi-Xuan Fan,
  • Zi-Xuan Fan,
  • Hao-Jia Chen,
  • Hao-Jia Chen,
  • Zhao Ge,
  • Zhao Ge,
  • Feng Zhu,
  • Hui-Jie Wang,
  • Bao-Nan Zhang,
  • Hai-Dong Sun,
  • Hai-Dong Sun,
  • Li-Min Feng

DOI
https://doi.org/10.3389/fphar.2021.668407
Journal volume & issue
Vol. 12

Abstract

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Coronavirus disease 2019 (COVID-19) is an emergent infectious pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is highly contagious and pathogenic. COVID-19 has rapidly swept across the world since it was first discovered in December 2019 and has drawn significant attention worldwide. During the early stages of the outbreak in China, traditional Chinese medicines (TCMs) were involved in the whole treatment process. As an indispensable part of TCM, Chinese patent medicines (CPMs) played an irreplaceable role in the prevention and treatment of this epidemic. Their use has achieved remarkable therapeutic efficacy during the period of medical observation and clinical treatment of mild, moderate, severe, and critical cases and during convalescence. In order to better propagate and make full use of the benefits of TCM in the treatment of COVID-19, this review will summarize the potential target of SARS-CoV-2 as well as the theoretical basis and clinical efficacy of recommended 22 CPMs by the National Health Commission and the Administration of TCM and local provinces or cities in the treatment of COVID-19. Additionally, the study will further analyze the drug composition, potential active ingredients, potential targets, regulated signaling pathways, and possible mechanisms for COVID-19 through anti-inflammatory and immunoregulation, antiviral, improve lung injury, antipyretic and organ protection to provide meaningful information about the clinical application of CPMs.

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