Development of a functional salivary gland tissue chip with potential for high-content drug screening

Yuanhui Song; Hitoshi Uchida; Azmeer Sharipol; Lindsay Piraino; Jared A. Mereness; Matthew H. Ingalls; Jonathan Rebhahn; Shawn D. Newlands; Lisa A. DeLouise; Catherine E. Ovitt; Danielle S. W. Benoit

doi:10.1038/s42003-021-01876-x

Communications Biology (Mar 2021)

Development of a functional salivary gland tissue chip with potential for high-content drug screening

Yuanhui Song,
Hitoshi Uchida,
Azmeer Sharipol,
Lindsay Piraino,
Jared A. Mereness,
Matthew H. Ingalls,
Jonathan Rebhahn,
Shawn D. Newlands,
Lisa A. DeLouise,
Catherine E. Ovitt,
Danielle S. W. Benoit

Affiliations

Yuanhui Song: Department of Biomedical Engineering, University of Rochester
Hitoshi Uchida: Center for Oral Biology, University of Rochester Medical Center
Azmeer Sharipol: Department of Biomedical Engineering, University of Rochester
Lindsay Piraino: Department of Biomedical Engineering, University of Rochester
Jared A. Mereness: Department of Biomedical Engineering, University of Rochester
Matthew H. Ingalls: Center for Oral Biology, University of Rochester Medical Center
Jonathan Rebhahn: David H. Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center
Shawn D. Newlands: Department of Otolaryngology, University of Rochester Medical Center
Lisa A. DeLouise: Department of Biomedical Engineering, University of Rochester
Catherine E. Ovitt: Center for Oral Biology, University of Rochester Medical Center
Danielle S. W. Benoit: Department of Biomedical Engineering, University of Rochester

DOI: https://doi.org/10.1038/s42003-021-01876-x
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 15

Abstract

Read online

Song, Uchida, and Sharipol et al. develop functional tissue mimetics for mouse and human salivary glands by combining engineered extracellular matrices with microbubble array technology. The resulting tissue mimetics emulate phenotype and function of salivary glands and provide promise for high-content/throughput drug testing.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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