Two New Secondary Metabolites from Xylaria sp. cfcc 87468
Fuqian Wang,
Shishi Han,
Song Hu,
Yongbo Xue,
Jianping Wang,
Hongfeng Xu,
Lu Chen,
Geng Zhang,
Yonghui Zhang
Affiliations
Fuqian Wang
Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, Hubei, China
Shishi Han
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China
Song Hu
Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, Hubei, China
Yongbo Xue
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China
Jianping Wang
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China
Hongfeng Xu
Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, Hubei, China
Lu Chen
Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, Hubei, China
Geng Zhang
Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, Hubei, China
Yonghui Zhang
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China
A new isocoumarin glycoside, 3R-(+)-5-O-[6'-O-acetyl]-α-D-glucopyranosyl-5-hydroxymellein (1), and a new phenylethanol glycoside, (−)-phenylethyl-8-O-α-L-rhamno-pyranoside (2), were isolated from the ethyl acetate extract of the fungus Xylaria sp. cfcc 87468, together with five known steroids, β-sitosterol (3), stigmast-4-en-3-one (4), ergosterol (5), (22E)-cholesta-4,6,8(14),22-tetraen-3-one (6), and 4α-methyl- ergosta-8(14),24(28)-dien-3β-ol (7). The structures of compounds 1 and 2 were elucidated by MS, extensive 1D and 2D NMR spectroscopy, and the circular dichroism (CD) spectroscopy.
