Nature Communications (Mar 2022)
De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report
- Shiv Gandhi,
- Jonathan Klein,
- Alexander J. Robertson,
- Mario A. Peña-Hernández,
- Michelle J. Lin,
- Pavitra Roychoudhury,
- Peiwen Lu,
- John Fournier,
- David Ferguson,
- Shah A. K. Mohamed Bakhash,
- M. Catherine Muenker,
- Ariktha Srivathsan,
- Elsio A. Wunder,
- Nicholas Kerantzas,
- Wenshuai Wang,
- Brett Lindenbach,
- Anna Pyle,
- Craig B. Wilen,
- Onyema Ogbuagu,
- Alexander L. Greninger,
- Akiko Iwasaki,
- Wade L. Schulz,
- Albert I. Ko
Affiliations
- Shiv Gandhi
- Section of Infectious Diseases, Department of Medicine, Yale University School of Medicine
- Jonathan Klein
- Department of Immunobiology, Yale University School of Medicine
- Alexander J. Robertson
- Department of Epidemiology of Microbial Diseases, Yale School of Public Health
- Mario A. Peña-Hernández
- Department of Immunobiology, Yale University School of Medicine
- Michelle J. Lin
- Department of Laboratory Medicine, University of Washington School of Medicine
- Pavitra Roychoudhury
- Department of Laboratory Medicine, University of Washington School of Medicine
- Peiwen Lu
- Department of Immunobiology, Yale University School of Medicine
- John Fournier
- Section of Infectious Diseases, Department of Medicine, Yale University School of Medicine
- David Ferguson
- Center for Outcomes Research and Evaluation, Yale New Haven Hospital
- Shah A. K. Mohamed Bakhash
- Department of Laboratory Medicine, University of Washington School of Medicine
- M. Catherine Muenker
- Department of Epidemiology of Microbial Diseases, Yale School of Public Health
- Ariktha Srivathsan
- Department of Epidemiology of Microbial Diseases, Yale School of Public Health
- Elsio A. Wunder
- Department of Epidemiology of Microbial Diseases, Yale School of Public Health
- Nicholas Kerantzas
- Department of Laboratory Medicine, Yale School of Medicine
- Wenshuai Wang
- Department of Molecular, Cellular and Developmental Biology, Yale University
- Brett Lindenbach
- Department of Microbial Pathogenesis, Yale School of Medicine
- Anna Pyle
- Department of Molecular, Cellular and Developmental Biology, Yale University
- Craig B. Wilen
- Department of Immunobiology, Yale University School of Medicine
- Onyema Ogbuagu
- Section of Infectious Diseases, Department of Medicine, Yale University School of Medicine
- Alexander L. Greninger
- Department of Laboratory Medicine, University of Washington School of Medicine
- Akiko Iwasaki
- Department of Immunobiology, Yale University School of Medicine
- Wade L. Schulz
- Center for Outcomes Research and Evaluation, Yale New Haven Hospital
- Albert I. Ko
- Section of Infectious Diseases, Department of Medicine, Yale University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-29104-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 8
Abstract
Here, the authors identify and validate the emergence of a SARS-CoV-2 resistance mutation to Remdesivir, associated with virological recrudesce in an immunocompromised patient with persistent COVID-19.
