Nature Communications (Jul 2022)

Postmitotic differentiation of human monocytes requires cohesin-structured chromatin

  • Julia Minderjahn,
  • Alexander Fischer,
  • Konstantin Maier,
  • Karina Mendes,
  • Margit Nuetzel,
  • Johanna Raithel,
  • Hanna Stanewsky,
  • Ute Ackermann,
  • Robert Månsson,
  • Claudia Gebhard,
  • Michael Rehli

DOI
https://doi.org/10.1038/s41467-022-31892-2
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 19

Abstract

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How chromatin structure and gene accessibility changes during monocyte differentiation is not clearly defined. Here the authors characterize the chromatin changes during macrophage or dendritic cell maturation from monocytes and the dependence of this upon cohesin and CTCF.