Nature Communications (Sep 2019)
Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling
- Nan Li,
- Yifan Wang,
- Shinya Neri,
- Yuanli Zhen,
- Lon Wolf R. Fong,
- Yawei Qiao,
- Xu Li,
- Zhen Chen,
- Clifford Stephan,
- Weiye Deng,
- Rui Ye,
- Wen Jiang,
- Shuxing Zhang,
- Yonghao Yu,
- Mien-Chie Hung,
- Junjie Chen,
- Steven H. Lin
Affiliations
- Nan Li
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Yifan Wang
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Shinya Neri
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Yuanli Zhen
- Department of Biochemistry, University of Texas Southwestern Medical Center
- Lon Wolf R. Fong
- The University of Texas Graduate School of Biomedical Sciences Houston
- Yawei Qiao
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Xu Li
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Zhen Chen
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Clifford Stephan
- Center for Translational Cancer Research, The Institute of Biosciences and Technology at Texas A&M University
- Weiye Deng
- Department of Radiation Oncology, University of Texas Southwestern Medical Center
- Rui Ye
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Wen Jiang
- Department of Radiation Oncology, University of Texas Southwestern Medical Center
- Shuxing Zhang
- Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center
- Yonghao Yu
- Department of Biochemistry, University of Texas Southwestern Medical Center
- Mien-Chie Hung
- The University of Texas Graduate School of Biomedical Sciences Houston
- Junjie Chen
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Steven H. Lin
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-019-12377-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
The LKB1/AMPK is crucial for maintaining cellular homeostasis and is often deregulated in tumours. Here, the authors show that the ribosylation of LKB1 by tankyrase-RNF146 axis results in attenuation of LKB1 pathway activation.
