Molecules (Feb 2023)

Co-Encapsulation of Drugs for Topical Application—A Review

  • Janaína Artem Ataide,
  • Julia Cedran Coco,
  • Érica Mendes dos Santos,
  • Viviane Beraldo-Araujo,
  • Jéssica Ribeiro Alves Silva,
  • Karine Cappuccio de Castro,
  • André Moreni Lopes,
  • Nina Filipczak,
  • Satya Siva Kishan Yalamarty,
  • Vladimir P. Torchilin,
  • Priscila Gava Mazzola

DOI
https://doi.org/10.3390/molecules28031449
Journal volume & issue
Vol. 28, no. 3
p. 1449

Abstract

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Achieving the best possible outcome for the therapy is the main goal of a medicine. Therefore, nanocarriers and co-delivery strategies were invented to meet this need, as they can benefit many diseases. This approach was applied specifically for cancer treatment, with some success. However, these strategies may benefit many other clinical issues. Skin is the largest and most exposed organ of the human body, with physiological and psychological properties. Due to its exposition and importance, it is not difficult to understand how many skin diseases may impact on patients’ lives, representing an important burden for society. Thus, this review aims to summarize the state of the art in research concerning nanocarriers and co-delivery strategies for topical agents’ applications targeting skin diseases. The challenge for the medicine of the future is to deliver the drug with spatial and temporal control. Therefore, the co-encapsulation of drugs and the appropriate form of administration for them are so important and remain as unmet needs.

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