Nature Communications (Mar 2023)
Characterization of SARS-CoV-2 Omicron BA.2.75 clinical isolates
- Ryuta Uraki,
- Shun Iida,
- Peter J. Halfmann,
- Seiya Yamayoshi,
- Yuichiro Hirata,
- Kiyoko Iwatsuki-Horimoto,
- Maki Kiso,
- Mutsumi Ito,
- Yuri Furusawa,
- Hiroshi Ueki,
- Yuko Sakai-Tagawa,
- Makoto Kuroda,
- Tadashi Maemura,
- Taksoo Kim,
- Sohtaro Mine,
- Noriko Iwamoto,
- Rong Li,
- Yanan Liu,
- Deanna Larson,
- Shuetsu Fukushi,
- Shinji Watanabe,
- Ken Maeda,
- Zhongde Wang,
- Norio Ohmagari,
- James Theiler,
- Will Fischer,
- Bette Korber,
- Masaki Imai,
- Tadaki Suzuki,
- Yoshihiro Kawaoka
Affiliations
- Ryuta Uraki
- Division of Virology, Institute of Medical Science, University of Tokyo
- Shun Iida
- Department of Pathology, National Institute of Infectious Diseases
- Peter J. Halfmann
- Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison
- Seiya Yamayoshi
- Division of Virology, Institute of Medical Science, University of Tokyo
- Yuichiro Hirata
- Department of Pathology, National Institute of Infectious Diseases
- Kiyoko Iwatsuki-Horimoto
- Division of Virology, Institute of Medical Science, University of Tokyo
- Maki Kiso
- Division of Virology, Institute of Medical Science, University of Tokyo
- Mutsumi Ito
- Division of Virology, Institute of Medical Science, University of Tokyo
- Yuri Furusawa
- Division of Virology, Institute of Medical Science, University of Tokyo
- Hiroshi Ueki
- Division of Virology, Institute of Medical Science, University of Tokyo
- Yuko Sakai-Tagawa
- Division of Virology, Institute of Medical Science, University of Tokyo
- Makoto Kuroda
- Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison
- Tadashi Maemura
- Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison
- Taksoo Kim
- Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison
- Sohtaro Mine
- Department of Pathology, National Institute of Infectious Diseases
- Noriko Iwamoto
- Disease Control and Prevention Center, National Center for Global Health and Medicine Hospital
- Rong Li
- Department of Animal, Dairy, and Veterinary Sciences, College of Agriculture and Applied Sciences, Utah State University
- Yanan Liu
- Department of Animal, Dairy, and Veterinary Sciences, College of Agriculture and Applied Sciences, Utah State University
- Deanna Larson
- Department of Animal, Dairy, and Veterinary Sciences, College of Agriculture and Applied Sciences, Utah State University
- Shuetsu Fukushi
- Department of Virology 1, National Institute of Infectious Diseases
- Shinji Watanabe
- Center for Influenza and Respiratory Virus Research, National Institute of Infectious Diseases
- Ken Maeda
- Department of Veterinary Science, National Institute of Infectious Diseases
- Zhongde Wang
- Department of Animal, Dairy, and Veterinary Sciences, College of Agriculture and Applied Sciences, Utah State University
- Norio Ohmagari
- Disease Control and Prevention Center, National Center for Global Health and Medicine Hospital
- James Theiler
- Space Data Science and Systems, Los Alamos National Laboratory
- Will Fischer
- Theoretical Biology and Biophysics, Los Alamos National Laboratory
- Bette Korber
- Theoretical Biology and Biophysics, Los Alamos National Laboratory
- Masaki Imai
- Division of Virology, Institute of Medical Science, University of Tokyo
- Tadaki Suzuki
- Department of Pathology, National Institute of Infectious Diseases
- Yoshihiro Kawaoka
- Division of Virology, Institute of Medical Science, University of Tokyo
- DOI
- https://doi.org/10.1038/s41467-023-37059-x
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 11
Abstract
Omicron subvariants may differ in their replicative fitness and their potential to cause more severe disease. In this study, the authors characterized Omicron BA.2.75 in a hamster model and found that it replicates more efficiently in the lungs than BA.2 and BA.5.
