Beilstein Journal of Nanotechnology (Sep 2015)

Nanofibers for drug delivery – incorporation and release of model molecules, influence of molecular weight and polymer structure

  • Jakub Hrib,
  • Jakub Sirc,
  • Radka Hobzova,
  • Zuzana Hampejsova,
  • Zuzana Bosakova,
  • Marcela Munzarova,
  • Jiri Michalek

DOI
https://doi.org/10.3762/bjnano.6.198
Journal volume & issue
Vol. 6, no. 1
pp. 1939 – 1945

Abstract

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Nanofibers were prepared from polycaprolactone, polylactide and polyvinyl alcohol using NanospiderTM technology. Polyethylene glycols with molecular weights of 2 000, 6 000, 10 000 and 20 000 g/mol, which can be used to moderate the release profile of incorporated pharmacologically active compounds, served as model molecules. They were terminated by aromatic isocyanate and incorporated into the nanofibers. The release of these molecules into an aqueous environment was investigated. The influences of the molecular length and chemical composition of the nanofibers on the release rate and the amount of released polyethylene glycols were evaluated. Longer molecules released faster, as evidenced by a significantly higher amount of released molecules after 72 hours. However, the influence of the chemical composition of nanofibers was even more distinct – the highest amount of polyethylene glycol molecules released from polyvinyl alcohol nanofibers, the lowest amount from polylactide nanofibers.

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