Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age

Aliza P. Wingo; Eric B. Dammer; Michael S. Breen; Benjamin A. Logsdon; Duc M. Duong; Juan C. Troncosco; Madhav Thambisetty; Thomas G. Beach; Geidy E. Serrano; Eric M. Reiman; Richard J. Caselli; James J. Lah; Nicholas T. Seyfried; Allan I. Levey; Thomas S. Wingo

doi:10.1038/s41467-019-09613-z

Nature Communications (Apr 2019)

Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age

Aliza P. Wingo,
Eric B. Dammer,
Michael S. Breen,
Benjamin A. Logsdon,
Duc M. Duong,
Juan C. Troncosco,
Madhav Thambisetty,
Thomas G. Beach,
Geidy E. Serrano,
Eric M. Reiman,
Richard J. Caselli,
James J. Lah,
Nicholas T. Seyfried,
Allan I. Levey,
Thomas S. Wingo

Affiliations

Aliza P. Wingo: Division of Mental Health, Atlanta VA Medical Center
Eric B. Dammer: Department of Biochemistry, Emory University School of Medicine
Michael S. Breen: Department of Psychiatry, Icahn School of Medicine at Mount Sinai
Benjamin A. Logsdon: Sage Bionetworks
Duc M. Duong: Department of Biochemistry, Emory University School of Medicine
Juan C. Troncosco: Johns Hopkins School of Medicine
Madhav Thambisetty: Unit of Clinical and Translational Neuroscience, Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health
Thomas G. Beach: Banner Sun Health Research Institute
Geidy E. Serrano: Banner Sun Health Research Institute
Eric M. Reiman: Banner Alzheimer’s Institute, Arizona State University and University of Arizona
Richard J. Caselli: Department of Neurology, Mayo Clinic
James J. Lah: Department of Neurology, Emory University School of Medicine
Nicholas T. Seyfried: Department of Biochemistry, Emory University School of Medicine
Allan I. Levey: Department of Neurology, Emory University School of Medicine
Thomas S. Wingo: Department of Neurology, Emory University School of Medicine

DOI: https://doi.org/10.1038/s41467-019-09613-z
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Cognitive abilities tend to decline over time in advanced age, yet some individuals experience stable abilities or rapid decline. Here the authors present a proteome-wide association study of cognitive trajectory, and identify 38 proteins associated with cognitive resilience.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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