Clinical Optometry (Jan 2022)

OSDI Outcomes Based on Patient Demographic and Wear Patterns in Prosthetic Replacement of the Ocular Surface Ecosystem

  • Asghari B,
  • Brocks D,
  • Carrasquillo KG,
  • Crowley E

Journal volume & issue
Vol. Volume 14
pp. 1 – 12

Abstract

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Bita Asghari, Daniel Brocks, Karen G Carrasquillo, Estelle Crowley BostonSight, Needham, MA, USACorrespondence: Bita Asghari Tel +1-781-726-7337Fax +1-781-726-7310Email [email protected]: To evaluate the impact of prosthetic replacement of the ocular surface ecosystem (BostonSight PROSE) treatment on symptom outcomes based on the Ocular Surface Disease Index (OSDI).Patients and Methods: This was a single-center, retrospective analysis of consecutive patients who initiated PROSE treatment between September 2017 and December 2019 by the same clinician. The primary outcome measure was to compare OSDI survey scores at baseline prior to PROSE treatment and at follow-up, after PROSE treatment. Indication for treatment, sex, age, device diameter, average wear time, preexisting mental illness, duration of PROSE wear, and status of PROSE wear at follow-up were also studied.Results: A total of 134 patients underwent PROSE treatment and completed a baseline OSDI survey during the study period. Forty-three patients completed a follow-up OSDI survey and were included in the study analysis. The most common treatment indications were keratoconjunctivitis sicca (n=27) and corneal ectasia (n=16). Baseline average OSDI score was 56.9± 23.7 for the 43 subjects who completed a subsequent OSDI survey. The last documented average follow-up OSDI for those 43 subjects was 23.8± 15.6, median (IQR) of 22.9 (10.4 to 32.3), and a statistically significant 54.7± 27.6% average improvement from baseline (p< 0.01). All patients, except for two, showed improvement in OSDI score. Statistically significant improvement occurred regardless of underlying diagnosis with no statistically significant difference based on age, sex, mental illness, or device diameter and no statistical correlation with average wear time, or duration of PROSE wear.Conclusion: PROSE treatment improves visual function and symptom relief as demonstrated by the OSDI survey. Sex, age, preexisting mental illness, device diameter, average wear time, and duration of wear had no statistically significant impact on OSDI outcomes.Keywords: PROSE, OSDI survey, scleral lens, ocular surface disease, corneal ectasia, dry eye

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