Communications Biology (May 2022)

Chord: an ensemble machine learning algorithm to identify doublets in single-cell RNA sequencing data

  • Ke-Xu Xiong,
  • Han-Lin Zhou,
  • Cong Lin,
  • Jian-Hua Yin,
  • Karsten Kristiansen,
  • Huan-Ming Yang,
  • Gui-Bo Li

DOI
https://doi.org/10.1038/s42003-022-03476-9
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 11

Abstract

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For the unmet need to choose the suitable doublet detection method, an ensemble machine learning algorithm called Chord was developed, which integrates multiple methods and achieves higher accuracy and stability on different scRNA-seq datasets.