High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation

Miglė Kišonaitė; Klemens Wild; Karine Lapouge; Thomas Ruppert; Irmgard Sinning

doi:10.1038/s41467-022-27967-9

Nature Communications (Jan 2022)

High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation

Miglė Kišonaitė,
Klemens Wild,
Karine Lapouge,
Thomas Ruppert,
Irmgard Sinning

Affiliations

Miglė Kišonaitė: Biochemiezentrum der Universität Heidelberg (BZH), INF328
Klemens Wild: Biochemiezentrum der Universität Heidelberg (BZH), INF328
Karine Lapouge: Biochemiezentrum der Universität Heidelberg (BZH), INF328
Thomas Ruppert: Zentrum für Molekulare Biologie der Universität Heidelberg, INF282
Irmgard Sinning: Biochemiezentrum der Universität Heidelberg (BZH), INF328

DOI: https://doi.org/10.1038/s41467-022-27967-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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High-resolution cryo-EM structures of a thermophilic 80S ribosome in two rotational states in complex with the protective factor Stm1, eEF2, and nascent chains are presented, providing insights into rRNA modifications and eukaryotic translation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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