The industrial anaerobe Clostridium acetobutylicum uses polyketides to regulate cellular differentiation

Nicolaus A. Herman; Seong Jong Kim; Jeffrey S. Li; Wenlong Cai; Hiroyuki Koshino; Wenjun Zhang

doi:10.1038/s41467-017-01809-5

Nature Communications (Nov 2017)

The industrial anaerobe Clostridium acetobutylicum uses polyketides to regulate cellular differentiation

Nicolaus A. Herman,
Seong Jong Kim,
Jeffrey S. Li,
Wenlong Cai,
Hiroyuki Koshino,
Wenjun Zhang

Affiliations

Nicolaus A. Herman: Department of Chemical and Biomolecular Engineering, University of California-Berkeley
Seong Jong Kim: Department of Chemical and Biomolecular Engineering, University of California-Berkeley
Jeffrey S. Li: Department of Chemical and Biomolecular Engineering, University of California-Berkeley
Wenlong Cai: Department of Chemical and Biomolecular Engineering, University of California-Berkeley
Hiroyuki Koshino: RIKEN Center for Sustainable Resource Science
Wenjun Zhang: Department of Chemical and Biomolecular Engineering, University of California-Berkeley

DOI: https://doi.org/10.1038/s41467-017-01809-5
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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Polyketides are secondary metabolites mainly found in aerobic organisms with wide applications in medicine and agriculture. Here, the authors uncover new polyketides native to the anaerobic bacterium Clostridium acetobutylicum and show their role in triggering sporulation and granulose accumulation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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