Weight-neutral early time-restricted eating improves glycemic variation and time in range without changes in inflammatory markers
Joanne Bruno,
Jeanne M. Walker,
Shabnam Nasserifar,
Dhairya Upadhyay,
Andrea Ronning,
Sally M. Vanegas,
Collin J. Popp,
Souptik Barua,
José O. Alemán
Affiliations
Joanne Bruno
Laboratory of Translational Obesity Research, New York University Langone Health, New York, NY 10016, USA; Holman Division of Endocrinology, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA; Corresponding author
Jeanne M. Walker
The Rockefeller University Hospital, New York, NY 10065, USA
Shabnam Nasserifar
Laboratory of Translational Obesity Research, New York University Langone Health, New York, NY 10016, USA; Holman Division of Endocrinology, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA
Dhairya Upadhyay
Division of Precision Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA
Andrea Ronning
The Rockefeller University Hospital, New York, NY 10065, USA
Sally M. Vanegas
Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA
Collin J. Popp
Department of Population Health, Institute for Excellence in Health Equity, New York University Langone Health, New York, NY 10016, USA
Souptik Barua
Division of Precision Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA
José O. Alemán
Laboratory of Translational Obesity Research, New York University Langone Health, New York, NY 10016, USA; Holman Division of Endocrinology, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA; Corresponding author
Summary: Early time-restricted eating (eTRE) is a dietary strategy that restricts caloric intake to the first 6–8 h of the day and can effect metabolic benefits independent of weight loss. However, the extent of these benefits is unknown. We conducted a randomized crossover feeding study to investigate the weight-independent effects of eTRE on glycemic variation, multiple time-in-range metrics, and levels of inflammatory markers. Ten adults with prediabetes were randomized to eTRE (8-h feeding window, 80% of calories consumed before 14:00 h) or usual feeding (50% of calories consumed after 16:00 h) for 1 week followed by crossover to the other schedule. Using continuous glucose monitoring, we showed that eTRE decreased glycemic variation (mean amplitude of glycemic excursion) and time in hyperglycemia greater than 140 mg/dL without affecting inflammatory markers (erythrocyte sedimentation rate and C-reactive protein). These data implicate eTRE as a candidate dietary intervention for the weight-independent management of dysglycemia in high-risk individuals.
