Impaired cytotoxicity associated with defective natural killer cell differentiation in myelodysplastic syndromes

Maryam Hejazi; Angela R. Manser; Julia Fröbel; Andrea Kündgen; Xiaoyi Zhao; Kathrin Schönberg; Ulrich Germing; Rainer Haas; Norbert Gattermann; Markus Uhrberg

doi:10.3324/haematol.2014.118679

Haematologica (May 2015)

Impaired cytotoxicity associated with defective natural killer cell differentiation in myelodysplastic syndromes

Maryam Hejazi,
Angela R. Manser,
Julia Fröbel,
Andrea Kündgen,
Xiaoyi Zhao,
Kathrin Schönberg,
Ulrich Germing,
Rainer Haas,
Norbert Gattermann,
Markus Uhrberg

Affiliations

Maryam Hejazi: Institute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany
Angela R. Manser: Institute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany
Julia Fröbel: Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany
Andrea Kündgen: Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany
Xiaoyi Zhao: Institute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany
Kathrin Schönberg: Institute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany
Ulrich Germing: Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany
Rainer Haas: Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany
Norbert Gattermann: Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany
Markus Uhrberg: Institute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany

DOI: https://doi.org/10.3324/haematol.2014.118679
Journal volume & issue: Vol. 100, no. 5

Abstract

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Natural killer cells are well known to mediate anti-leukemic responses in myeloid leukemia but their role in myelodysplastic syndromes is not well understood. Here, in a cohort of newly diagnosed patients (n=75), widespread structural and functional natural killer cell defects were identified. One subgroup of patients (13%) had a selective deficiency of peripheral natural killer cells (count

Published in Haematologica

ISSN: 0390-6078 (Print); 1592-8721 (Online)
Publisher: Ferrata Storti Foundation
Country of publisher: Italy
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs
Website: http://www.haematologica.org

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