Nature Communications (Sep 2021)
Chlamydia evasion of neutrophil host defense results in NLRP3 dependent myeloid-mediated sterile inflammation through the purinergic P2X7 receptor
- Chunfu Yang,
- Lei Lei,
- John W. Marshall Collins,
- Michael Briones,
- Li Ma,
- Gail L. Sturdevant,
- Hua Su,
- Anuj K. Kashyap,
- David Dorward,
- Kevin W. Bock,
- Ian N. Moore,
- Christine Bonner,
- Chih-Yu Chen,
- Craig A. Martens,
- Stacy Ricklefs,
- Masahiro Yamamoto,
- Kiyoshi Takeda,
- Yoichiro Iwakura,
- Grant McClarty,
- Harlan D. Caldwell
Affiliations
- Chunfu Yang
- Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Lei Lei
- Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- John W. Marshall Collins
- Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Michael Briones
- Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Li Ma
- Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Gail L. Sturdevant
- Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Hua Su
- Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Anuj K. Kashyap
- Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- David Dorward
- Research Technology Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Kevin W. Bock
- Infectious Disease Pathogenesis Section, Comparative Medicine Branch, National Institutes of Allergy and Infectious Diseases, National Institutes of Health
- Ian N. Moore
- Infectious Disease Pathogenesis Section, Comparative Medicine Branch, National Institutes of Allergy and Infectious Diseases, National Institutes of Health
- Christine Bonner
- National Microbiology Laboratory, Public Health Agency of Canada
- Chih-Yu Chen
- National Microbiology Laboratory, Public Health Agency of Canada
- Craig A. Martens
- Genomics Unit, Research Technology Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Stacy Ricklefs
- Genomics Unit, Research Technology Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Masahiro Yamamoto
- Department of Immunoparasitology, Research Institute for Microbial Diseases (RIMD), Osaka University
- Kiyoshi Takeda
- Laboratory of Mucosal Immunology, WPI Immunology Frontier Research Center, Osaka University
- Yoichiro Iwakura
- Institute for Biomedical Sciences, Tokyo University of Science
- Grant McClarty
- Department of Medical Microbiology, University of Manitoba
- Harlan D. Caldwell
- Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-021-25749-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Myeloid cells are implicated in the innate immune and inflammatory response during infection with Chlamydia trachomatis. Here the authors show the evasion of the neutrophil response to infection and concomitant induction of sterile immunity via the purinergic P2X7 receptor.
