International Journal of Infectious Diseases (Apr 2021)
Recrudescence of a high parasitaemia, severe Plasmodium falciparum malaria episode, treated by artesunate monotherapy
- Sophie Landre,
- Anne-Lise Bienvenu,
- Patrick Miailhes,
- Paul Abraham,
- Marie Simon,
- Agathe Becker,
- Anne Conrad,
- Guillaume Bonnot,
- Yobouet Ines Kouakou,
- Christian Chidiac,
- Gilles Leboucher,
- Thomas Rimmelé,
- Laurent Argaud,
- Stephane Picot
Affiliations
- Sophie Landre
- Service des Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 69004 Lyon, France
- Anne-Lise Bienvenu
- Service Pharmacie, Groupement Hospitalier Nord, Hospices Civils de Lyon, 69004 Lyon, France
- Patrick Miailhes
- Service des Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 69004 Lyon, France
- Paul Abraham
- Anesthesiology and Critical Care Medicine, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France
- Marie Simon
- Service de Médecine Intensive-Réanimation, Hôpital Edouard Herriot, Hospices Civils de Lyon, 69437 Lyon Cedex 03, France
- Agathe Becker
- Service des Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 69004 Lyon, France
- Anne Conrad
- Service des Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 69004 Lyon, France
- Guillaume Bonnot
- Univ Lyon, Malaria Research Unit, UMR 5246 CNRS-INSA-CPE-University Lyon1, 69100 Villeurbanne, France
- Yobouet Ines Kouakou
- Univ Lyon, Malaria Research Unit, UMR 5246 CNRS-INSA-CPE-University Lyon1, 69100 Villeurbanne, France; Institute of Parasitology and Medical Mycology, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 69004 Lyon, France
- Christian Chidiac
- Service des Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 69004 Lyon, France
- Gilles Leboucher
- Service Pharmacie, Groupement Hospitalier Nord, Hospices Civils de Lyon, 69004 Lyon, France
- Thomas Rimmelé
- Anesthesiology and Critical Care Medicine, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France
- Laurent Argaud
- Service de Médecine Intensive-Réanimation, Hôpital Edouard Herriot, Hospices Civils de Lyon, 69437 Lyon Cedex 03, France
- Stephane Picot
- Univ Lyon, Malaria Research Unit, UMR 5246 CNRS-INSA-CPE-University Lyon1, 69100 Villeurbanne, France; Institute of Parasitology and Medical Mycology, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 69004 Lyon, France; Corresponding author at: Malaria Research Unit, UMR 5246 CNRS-INSA-CPE-University Lyon1, F-69100 Villeurbanne, France.
- Journal volume & issue
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Vol. 105
pp. 345 – 348
Abstract
A patient presenting with severe malaria, with hyperparasitaemia, received 7-day artesunate monotherapy. A severe recrudescence was detected and attributed to hyperparasitaemia, monotherapy and a polyclonal infection without Kelch 13 gene mutation. A second treatment with artesunate, then quinine, followed by artemether-lumefantrine, was successful.
