Nature Communications (Mar 2022)
βIV-spectrin as a stalk cell-intrinsic regulator of VEGF signaling
- Eun-A Kwak,
- Christopher C. Pan,
- Aaron Ramonett,
- Sanjay Kumar,
- Paola Cruz-Flores,
- Tasmia Ahmed,
- Hannah R. Ortiz,
- Jeffrey J. Lochhead,
- Nathan A. Ellis,
- Ghassan Mouneimne,
- Teodora G. Georgieva,
- Yeon Sun Lee,
- Todd W. Vanderah,
- Tally Largent-Milnes,
- Peter J. Mohler,
- Thomas J. Hund,
- Paul R. Langlais,
- Karthikeyan Mythreye,
- Nam Y. Lee
Affiliations
- Eun-A Kwak
- Department of Pharmacology, University of Arizona
- Christopher C. Pan
- Department of Pharmacology and Cancer Biology, Duke University
- Aaron Ramonett
- Department of Pharmacology, University of Arizona
- Sanjay Kumar
- Division of Biology, Indian Institute of Science Education and Research
- Paola Cruz-Flores
- Department of Chemistry & Biochemistry, University of Arizona
- Tasmia Ahmed
- Department of Chemistry & Biochemistry, University of Arizona
- Hannah R. Ortiz
- Department of Pharmacology, University of Arizona
- Jeffrey J. Lochhead
- Department of Pharmacology, University of Arizona
- Nathan A. Ellis
- Cellular and Molecular Medicine, University of Arizona
- Ghassan Mouneimne
- Cellular and Molecular Medicine, University of Arizona
- Teodora G. Georgieva
- BIO5 Institute, University of Arizona
- Yeon Sun Lee
- Department of Pharmacology, University of Arizona
- Todd W. Vanderah
- Department of Pharmacology, University of Arizona
- Tally Largent-Milnes
- Department of Pharmacology, University of Arizona
- Peter J. Mohler
- Department of Physiology and Cell Biology, Ohio State University
- Thomas J. Hund
- Department of Biomedical Engineering, Ohio State University
- Paul R. Langlais
- Department of Internal Medicine, University of Arizona
- Karthikeyan Mythreye
- Department of Pathology, University of Alabama at Birmingham
- Nam Y. Lee
- Department of Pharmacology, University of Arizona
- DOI
- https://doi.org/10.1038/s41467-022-28933-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Defective angiogenesis remains a high source of morbidity in multiple disorders. Here they show that βIV-spectrin, a membrane-associated cytoskeletal protein, is essential for regulation of endothelial tip cell populations and VEGF signaling during sprouting angiogenesis.
