Guoji Yanke Zazhi (May 2016)

Effect of 0.5g/L cyclosporine A for symptom and sign scores in patients with moderate to severe dry eye

  • Su-Ying Yu,
  • Cheng-Rong Fu

DOI
https://doi.org/10.3980/j.issn.1672-5123.2016.5.32
Journal volume & issue
Vol. 16, no. 5
pp. 920 – 922

Abstract

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AIM:To investigate the effect of 0.5g/L cyclosporine A for symptom and sign scores in patients with moderate to severe dry eye.METHODS:Eighty patients(160 eyes)with moderate to severe dry eye were divided into two groups by double-blind and random principles:40 patients(80 eyes)in observation group were treated with 10g/L sodium carboxymethyl cellulose and 0.5g/L cyclosporine A eye drops, 40 patients(80 eyes)in the control group were treated with 10g/L sodium carboxymethyl cellulose eye drops. The changes of ocular sign and symptom scores were compared between the two groups.RESULTS:The total effective rate of observation group was 95.0%, which was significantly higher than that of control group(85.0%, PPPP>0.05). After treatment, the four parameters of observation group were improved significantly(PPPCONCLUSION:The 0.5g/L cyclosporine A eye drops can effectively relieve the symptoms and signs of moderate to severe dry eye, promote tear secretion, and improve ocular surface environment. The treatment effect is good.

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