Effects of DISC1 Polymorphisms on Resting-State Spontaneous Neuronal Activity in the Early-Stage of Schizophrenia

Ningzhi Gou; Ningzhi Gou; Zhening Liu; Zhening Liu; Lena Palaniyappan; Mingding Li; Yunzhi Pan; Yunzhi Pan; Xudong Chen; Xudong Chen; Haojuan Tao; Haojuan Tao; Guowei Wu; Guowei Wu; Xuan Ouyang; Xuan Ouyang; Zheng Wang; Zheng Wang; Taotao Dou; Zhimin Xue; Zhimin Xue; Weidan Pu; Weidan Pu

doi:10.3389/fpsyt.2018.00137

Frontiers in Psychiatry (May 2018)

Effects of DISC1 Polymorphisms on Resting-State Spontaneous Neuronal Activity in the Early-Stage of Schizophrenia

Ningzhi Gou,
Ningzhi Gou,
Zhening Liu,
Zhening Liu,
Lena Palaniyappan,
Mingding Li,
Yunzhi Pan,
Yunzhi Pan,
Xudong Chen,
Xudong Chen,
Haojuan Tao,
Haojuan Tao,
Guowei Wu,
Guowei Wu,
Xuan Ouyang,
Xuan Ouyang,
Zheng Wang,
Zheng Wang,
Taotao Dou,
Zhimin Xue,
Zhimin Xue,
Weidan Pu,
Weidan Pu

Affiliations

Ningzhi Gou: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China
Ningzhi Gou: Key Laboratory of Psychiatry and Mental Health of Hunan Province, The China National Clinical Research Center for Mental Health Disorders, National Technology Institute of Psychiatry, Changsha, China
Zhening Liu: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China
Zhening Liu: Key Laboratory of Psychiatry and Mental Health of Hunan Province, The China National Clinical Research Center for Mental Health Disorders, National Technology Institute of Psychiatry, Changsha, China
Lena Palaniyappan: Departments of Psychiatry and Medical Biophysics & Robarts and Lawson Research Institutes, University of Western Ontario, London, ON, Canada
Mingding Li: Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China
Yunzhi Pan: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China
Yunzhi Pan: Key Laboratory of Psychiatry and Mental Health of Hunan Province, The China National Clinical Research Center for Mental Health Disorders, National Technology Institute of Psychiatry, Changsha, China
Xudong Chen: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China
Xudong Chen: Key Laboratory of Psychiatry and Mental Health of Hunan Province, The China National Clinical Research Center for Mental Health Disorders, National Technology Institute of Psychiatry, Changsha, China
Haojuan Tao: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China
Haojuan Tao: Key Laboratory of Psychiatry and Mental Health of Hunan Province, The China National Clinical Research Center for Mental Health Disorders, National Technology Institute of Psychiatry, Changsha, China
Guowei Wu: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China
Guowei Wu: Key Laboratory of Psychiatry and Mental Health of Hunan Province, The China National Clinical Research Center for Mental Health Disorders, National Technology Institute of Psychiatry, Changsha, China
Xuan Ouyang: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China
Xuan Ouyang: Key Laboratory of Psychiatry and Mental Health of Hunan Province, The China National Clinical Research Center for Mental Health Disorders, National Technology Institute of Psychiatry, Changsha, China
Zheng Wang: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China
Zheng Wang: Key Laboratory of Psychiatry and Mental Health of Hunan Province, The China National Clinical Research Center for Mental Health Disorders, National Technology Institute of Psychiatry, Changsha, China
Taotao Dou: Department of Neurosurgery, The First affiliated Hospital of Xinjiang Medical University, Urumqi, China
Zhimin Xue: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China
Zhimin Xue: Key Laboratory of Psychiatry and Mental Health of Hunan Province, The China National Clinical Research Center for Mental Health Disorders, National Technology Institute of Psychiatry, Changsha, China
Weidan Pu: Medical Psychological Center, Second Xiangya Hospital, Central South University, Changsha, China
Weidan Pu: Medical Psychological Institute of Central South University, Changsha, China

DOI: https://doi.org/10.3389/fpsyt.2018.00137
Journal volume & issue: Vol. 9

Abstract

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Background: Localized abnormalities in the synchrony of spontaneous neuronal activity, measured with regional homogeneity (ReHo), has been consistently reported in patients with schizophrenia (SCZ) and their unaffected siblings. To date, little is known about the genetic influences affecting the spontaneous neuronal activity in SCZ. DISC1, a strong susceptible gene for SCZ, has been implicated in neuronal excitability and synaptic function possibly associated with regional spontaneous neuronal activity. This study aimed to examine the effects of DISC1 variations on the regional spontaneous neuronal activity in SCZ.Methods: Resting-state fMRI data were obtained from 28 SCZ patients and 21 healthy controls (HC) for ReHo analysis. Six single nucleotide polymorphisms (SNPs) of DISC1 gene were genotyped using the PCR and direct sequencing.Results: Significant diagnosis × genotype interactions were noted for three SNPs (rs821616, rs821617, and rs2738880). For rs821617, the interactions were localized to the precuneus, basal ganglia and pre-/post-central regions. Significant interactive effects were identified at the temporal and post-central gyri for rs821616 (Ser704Cys) and the inferior temporal gyrus for rs2738880. Furthermore, post-hoc analysis revealed that the DISC1 variations on these SNPs exerted different influences on ReHo between SCZ patients and HC.Conclusion: To our knowledge this is the first study to unpick the influence of DISC1 variations on spontaneous neuronal activity in SCZ; Given the emerging evidence that ReHo is a stable inheritable phenotype for schizophrenia, our findings suggest the DISC1 variations are possibly an inheritable source for the altered ReHo in this disorder.

Published in Frontiers in Psychiatry

ISSN: 1664-0640 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system: Psychiatry
Website: https://www.frontiersin.org/journals/psychiatry

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