Nature Communications (Mar 2019)

Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons

  • D. Zada,
  • I. Bronshtein,
  • T. Lerer-Goldshtein,
  • Y. Garini,
  • L. Appelbaum

DOI
https://doi.org/10.1038/s41467-019-08806-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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Do single neurons require sleep and what is the conserved cellular function of sleep? In this paper, the authors use real-time imaging of chromosomes in individual cells within live zebrafish to show that sleep increases chromosome dynamics, which are necessary to reduce DNA damage that is accumulated during wakefulness.