Neural Regeneration Research (Jan 2015)
Matrix metalloproteinase 9 level as an indicator for restenosis following cervical and intracranial angioplasty and stenting
- Jun-peng Liu,
- Yin-zhou Wang,
- Yong-kun Li,
- Qiong Cheng,
- Zheng Zheng
Affiliations
- Jun-peng Liu
- Yin-zhou Wang
- Yong-kun Li
- Qiong Cheng
- Zheng Zheng
- DOI
- https://doi.org/10.4103/1673-5374.155439
- Journal volume & issue
-
Vol. 10,
no. 4
pp. 631 – 635
Abstract
Cervical and intracranial angioplasty and stenting is an effective and safe method of reducing the risk of ischemic stroke, but it may be affected by in-stent restenosis. The present study investigated serum level of matrix metalloproteinase 9 as a predictor of restenosis after 40 patients underwent cervical and/or intracranial angioplasty and stenting. Results showed that restenosis occurred in 30% (3/10) of patients when the serum level of matrix metalloproteinase 9 at 3 days after surgery was 2.5 times higher than preoperative level. No restenosis occurred when the serum level of matrix metalloproteinase 9 at 3 days after surgery was not 2.5 times higher than preoperative level. Restenosis occurred in 12% (2/17) of patients when the serum level of matrix metalloproteinase 9 was higher than preoperative level for more than 30 days after surgery, but only occurred in 4% (1/23) of patients when the serum level of matrix metalloproteinase 9 was higher than preoperative level for less than 30 days after surgery. However, the differences observed were not statistically significant (P > 0.05). Experimental findings indicate that when the serum level of matrix metalloproteinase 9 is 2.5 times higher than preoperative level at 3 days after cervical and intracranial angioplasty and stenting, it may serve as a predictor of in-stent restenosis.
Keywords
- spinal cord injury
- propriospinal system
- neural plasticity
- fiber sprouting
- neural repair
- compensation
- regeneration
- propriospinal detours
- neurotrophic factors
- cell-adhesive ligands
- dorsal root ganglia
- L1CAM
- nerve growth factor
- biomaterials
- elastin-like proteins
- Alzheimer′s disease
- AMPK
- apoptosis
- autophagy
- central nervous system
- CCN4
- EGF
- diabetes mellitus
- erythropoietin
- EPO
- FGF
- IGF-1
- mTOR
- neuron
- neuropathy
- oxidative stress
- psychiatric
- stem cells
- WISP1
- Wnt
- peripheral nerve injury
- nerve graft
- nerve conduit
- Wallerian degeneration
- neurotrophic factors
- veins
- autografts
- nerve regeneration
- nerve regeneration
- neuroprotection
- resveratrol
- cerebral ischemia
- cerebral infarction
- matrix metalloproteinase
- molecular docking
- extracellular matrix
- neural regeneration
- nerve regeneration
- vagus nerve stimulation
- cerebral ischemia
- inflammatory cytokines
- infarct volume
- neurological function
- NSFC grants
- neural regeneration
- nerve regeneration
- Xingnao Kaiqiao needling method
- ischemic stroke
- randomized controlled trial
- systemic reviews
- meta-analysis
- long-term efficacy
- mortality
- recurrence
- disability
- adverse reactions
- health economics indicators
- neural regeneration
- nerve regeneration
- DDPH
- cerebral ischemia
- hippocampus
- blood flow
- isolated basilar artery
- dose-response curve
- NSFC grant
- neural regeneration
- nerve regeneration
- traumatic brain injury
- coma
- median nerve electrical stimulation
- wake-promoting
- orexin-A
- OX1R
- NSFC grants
- neural regeneration
- nerve regeneration
- seizure
- antiepileptic drugs
- immature brain
- hippocampus
- synaptic plasticity
- glutamate receptor
- NSFC grant
- neural regeneration
- nerve regeneration
- puerarin
- in vitro experiments
- co-culture
- neurons
- astrocytes
- Transwell
- neonatal rats
- neural regeneration
- nerve regeneration
- brain injury
- inflammatory reaction
- interleukin-6
- voltage-gated Na + channel
- cortical neurons
- cerebrospinal fluid
- neuroimmunomodulation
- neuroprotection
- action potential
- patch clamp
- neurophysiology
- NSFC grants
- neural regeneration
- nerve regeneration
- brain injury
- cognition disorders
- diagnostic techniques
- Wechsler Intelligence Scale
- event-related potential
- neuronal plasticity
- electrophysiology
- neuropsychology
- activity of daily living
- work capacity evaluation
- electroencephalogram
- neural regeneration
- NSFC grant
- nerve regeneration
- cerebral palsy
- corticospinal tract
- diffusion tensor
- hemiplegia
- motor
- rehabilitation
- neural regeneration
- nerve regeneration
- matrix metalloproteinase 9
- cervical and intracranial angioplasty and stenting
- restenosis
- intracranial artery stenosis
- neural regeneration