Correlation Between Immune Lymphoid Cells and Plasmacytoid Dendritic Cells in Human Colon Cancer

Jing Wu; Hang Cheng; Hang Cheng; Helei Wang; Helei Wang; Guoxia Zang; Lingli Qi; Lingli Qi; Xinping Lv; Chunyan Liu; Chunyan Liu; Shan Zhu; Mingyou Zhang; Jiuwei Cui; Hideki Ueno; Yong-Jun Liu; Jian Suo; Jingtao Chen; Jingtao Chen

doi:10.3389/fimmu.2021.601611

Frontiers in Immunology (Feb 2021)

Correlation Between Immune Lymphoid Cells and Plasmacytoid Dendritic Cells in Human Colon Cancer

Jing Wu,
Hang Cheng,
Hang Cheng,
Helei Wang,
Helei Wang,
Guoxia Zang,
Lingli Qi,
Lingli Qi,
Xinping Lv,
Chunyan Liu,
Chunyan Liu,
Shan Zhu,
Mingyou Zhang,
Jiuwei Cui,
Hideki Ueno,
Yong-Jun Liu,
Jian Suo,
Jingtao Chen,
Jingtao Chen

Affiliations

Jing Wu: Institute of Translational Medicine, The First Hospital, Jilin University, Changchun, China
Hang Cheng: Institute of Translational Medicine, The First Hospital, Jilin University, Changchun, China
Hang Cheng: Department of Pediatrics, The First Hospital, Jilin University, Changchun, China
Helei Wang: Institute of Translational Medicine, The First Hospital, Jilin University, Changchun, China
Helei Wang: Department of Stomach Colorectal Anal Surgery, The First Hospital, Jilin University, Changchun, China
Guoxia Zang: Institute of Translational Medicine, The First Hospital, Jilin University, Changchun, China
Lingli Qi: Institute of Translational Medicine, The First Hospital, Jilin University, Changchun, China
Lingli Qi: Department of Pediatric Gastroenterology, The First Hospital, Jilin University, Changchun, China
Xinping Lv: Institute of Translational Medicine, The First Hospital, Jilin University, Changchun, China
Chunyan Liu: Institute of Translational Medicine, The First Hospital, Jilin University, Changchun, China
Chunyan Liu: Department of Gynecology, The First Hospital, Jilin University, Changchun, China
Shan Zhu: Institute of Translational Medicine, The First Hospital, Jilin University, Changchun, China
Mingyou Zhang: Department of Cardiovascular Center, The First Hospital, Jilin University, Changchun, China
Jiuwei Cui: Cancer Center, The First Hospital, Jilin University, Changchun, China
Hideki Ueno: Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States
Yong-Jun Liu: Department of Research and Development of Sanofi, Cambridge, MA, United States
Jian Suo: Department of Stomach Colorectal Anal Surgery, The First Hospital, Jilin University, Changchun, China
Jingtao Chen: Institute of Translational Medicine, The First Hospital, Jilin University, Changchun, China
Jingtao Chen: 0Key Laboratory of Organ Regeneration & Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, China

DOI: https://doi.org/10.3389/fimmu.2021.601611
Journal volume & issue: Vol. 12

Abstract

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BackgroundInnate lymphoid cells (ILCs), so far studied mostly in mouse models, are important tissue-resident innate immune cells that play important roles in the colorectal cancer microenvironment and maintain mucosal tissue homeostasis. Plasmacytoid dendritic cells (pDCs) present complexity in various tumor types and are correlated with poor prognosis. pDCs can promote HIV-1–induced group 3 ILC (ILC3) depletion through the CD95 pathway. However, the role of ILC3s in human colon cancer and their correlation with other immune cells, especially pDCs, remain unclear.MethodsWe characterized ILCs and pDCs in the tumor microenvironment of 58 colon cancer patients by flow cytometry and selected three patients for RNA sequencing.ResultsILC3s were negatively correlated, and pDCs were positively correlated, with cancer pathological stage. There was a negative correlation between the numbers of ILC3s and pDCs in tumor tissues. RNA sequencing confirmed the correlations between ILC3s and pDCs and highlighted the potential function of many ILC- and pDC-associated differentially expressed genes in the regulation of tumor immunity. pDCs can induce apoptosis of ILC3s through the CD95 pathway in the tumor-like microenvironment.ConclusionsOne of the interactions between ILC3s and pDCs is via the CD95 pathway, which may help explain the role of ILC3s in colon cancer.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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