Extracellular collagen matrix in the treatment of chronic wounds in patients with diabetic foot syndrome

Abstract

Background. Treatment of chronic wounds in patients suffering from diabetic foot syndrome is one of the serious problems of practical surgery. Despite the constant improvement of methods aimed at improving the results of treatment of purulent-necrotic complications in these patients and preventing their occurrence in general, their frequency remains at the same level. An important factor influencing the slowdown of reparative processes in patients with diabetes mellitus is the presence of oxidative stress in the cells of the wound defect area. In conditions of diabetic angiopathy, the effectiveness of systemic pharmacotherapy is due to the impossibility of adequate delivery of drugs directly to the purulent-necrotic focus, which leads to the search for new methods of local treatment. Materials and methods. The results of treatment of 20 patients suffering from the neuroischemic form of diabetic foot syndrome with long-term non-healing wounds of the foot and lower leg were analyzed. In addition to standard therapy, the patients of the main group underwent the application of collagen gel from a matrix impregnated with antioxidants. Patients in the comparison group were treated only with standard therapy. The rate of reduction of the wound surface area and the activity of the microcirculatory bed in the area of the wound defect were evaluated. Results and conclusions. In patients of the main groups, shorter wound healing times were noted than in patients of the comparison group, as well as improved tissue microcirculation against the background of restoring balance in the lipid peroxidation system.

Keywords

• extracellular collagen matrix
• antioxidants
• blood microcirculation
• oxidative stress
• chronic wound
• diabetes mellitus
• diabetic foot syndrome