Nature Communications (Oct 2018)

Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals promutagenic DNA repair intermediate

  • Melike Çağlayan,
  • Samuel H. Wilson

DOI
https://doi.org/10.1038/s41467-018-06700-5
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 4

Abstract

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Incorporation of mismatched nucleotides during DNA replication or repair can lead to mutagenesis. Here the authors reveal that DNA ligase can ligate NHEJ intermediates following incorporation of 8-oxodGTP or dGTP opposite T by DNA Polymerase mu (Pol mu) in vitro, which suggests that Pol mu could cause promutagenic mismatches during DSB repair.