Synthesis of Triterpenoid-Derived α-Acyloxycarboxamides via Passerini Reaction

Abstract

Herein we describe the synthesis of a small series of α-acyloxycarboxamides via a facile and efficient one-pot procedure, employing a plant-derived triterpenoid as carboxylic acid component. The products were obtained in overall yields of 25 to 79%, while we scoped the effect of the nature of the aldehyde component on the reaction yields.

Keywords

• Passerini reaction (P-3CR)
• α-acyloxycarboxamides
• triterpenoid