Nature Communications (Feb 2023)
Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants
- Haisheng Yu,
- Banghui Liu,
- Yudi Zhang,
- Xijie Gao,
- Qian Wang,
- Haitao Xiang,
- Xiaofang Peng,
- Caixia Xie,
- Yaping Wang,
- Peiyu Hu,
- Jingrong Shi,
- Quan Shi,
- Pingqian Zheng,
- Chengqian Feng,
- Guofang Tang,
- Xiaopan Liu,
- Liliangzi Guo,
- Xiumei Lin,
- Jiaojiao Li,
- Chuanyu Liu,
- Yaling Huang,
- Naibo Yang,
- Qiuluan Chen,
- Zimu Li,
- Mengzhen Su,
- Qihong Yan,
- Rongjuan Pei,
- Xinwen Chen,
- Longqi Liu,
- Fengyu Hu,
- Dan Liang,
- Bixia Ke,
- Changwen Ke,
- Feng Li,
- Jun He,
- Meiniang Wang,
- Ling Chen,
- Xiaoli Xiong,
- Xiaoping Tang
Affiliations
- Haisheng Yu
- Guangzhou Eighth People’s Hospital, Guangzhou Medical University
- Banghui Liu
- The State Key Laboratory of Respiratory Disease, CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong Provincial Key Laboratory of Biocomputing, Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, the Chinese Academy of Sciences
- Yudi Zhang
- The State Key Laboratory of Respiratory Disease, CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong Provincial Key Laboratory of Biocomputing, Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, the Chinese Academy of Sciences
- Xijie Gao
- Bioland Laboratory (Guangzhou Regenerative Medicine and Health—Guangdong Laboratory)
- Qian Wang
- State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University
- Haitao Xiang
- BGI-Shenzhen
- Xiaofang Peng
- Guangdong Provincial Center for Disease Control and Prevention
- Caixia Xie
- BGI-Shenzhen
- Yaping Wang
- Guangzhou Eighth People’s Hospital, Guangzhou Medical University
- Peiyu Hu
- Bioland Laboratory (Guangzhou Regenerative Medicine and Health—Guangdong Laboratory)
- Jingrong Shi
- Guangzhou Eighth People’s Hospital, Guangzhou Medical University
- Quan Shi
- BGI-Shenzhen
- Pingqian Zheng
- Bioland Laboratory (Guangzhou Regenerative Medicine and Health—Guangdong Laboratory)
- Chengqian Feng
- Guangzhou Eighth People’s Hospital, Guangzhou Medical University
- Guofang Tang
- Guangzhou Eighth People’s Hospital, Guangzhou Medical University
- Xiaopan Liu
- BGI-Shenzhen
- Liliangzi Guo
- Guangzhou Eighth People’s Hospital, Guangzhou Medical University
- Xiumei Lin
- BGI-Shenzhen
- Jiaojiao Li
- Guangzhou Eighth People’s Hospital, Guangzhou Medical University
- Chuanyu Liu
- BGI-Shenzhen
- Yaling Huang
- BGI-Shenzhen
- Naibo Yang
- BGI-Shenzhen
- Qiuluan Chen
- Bioland Laboratory (Guangzhou Regenerative Medicine and Health—Guangdong Laboratory)
- Zimu Li
- The State Key Laboratory of Respiratory Disease, CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong Provincial Key Laboratory of Biocomputing, Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, the Chinese Academy of Sciences
- Mengzhen Su
- The State Key Laboratory of Respiratory Disease, CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong Provincial Key Laboratory of Biocomputing, Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, the Chinese Academy of Sciences
- Qihong Yan
- The State Key Laboratory of Respiratory Disease, CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong Provincial Key Laboratory of Biocomputing, Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, the Chinese Academy of Sciences
- Rongjuan Pei
- State Key Laboratory of Virology, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences
- Xinwen Chen
- Guangzhou Laboratory, Guangzhou International Bio Island
- Longqi Liu
- BGI-Shenzhen
- Fengyu Hu
- Guangzhou Eighth People’s Hospital, Guangzhou Medical University
- Dan Liang
- Guangdong Provincial Center for Disease Control and Prevention
- Bixia Ke
- Guangdong Provincial Center for Disease Control and Prevention
- Changwen Ke
- Guangdong Provincial Center for Disease Control and Prevention
- Feng Li
- Guangzhou Eighth People’s Hospital, Guangzhou Medical University
- Jun He
- The State Key Laboratory of Respiratory Disease, CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong Provincial Key Laboratory of Biocomputing, Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, the Chinese Academy of Sciences
- Meiniang Wang
- BGI-Shenzhen
- Ling Chen
- Guangzhou Eighth People’s Hospital, Guangzhou Medical University
- Xiaoli Xiong
- The State Key Laboratory of Respiratory Disease, CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong Provincial Key Laboratory of Biocomputing, Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, the Chinese Academy of Sciences
- Xiaoping Tang
- Guangzhou Eighth People’s Hospital, Guangzhou Medical University
- DOI
- https://doi.org/10.1038/s41467-023-36761-0
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 14
Abstract
In this study, authors identified neutralizing antibodies by isolating B cells from SARS-CoV-2 Delta infected patients and detect altered structural features, likely introduced by somatic hypermutation, that are involved in epitope binding and increase neutralization breadth against virus variants.
