Nature Communications (Jun 2016)

A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries

  • Aman P. Mann,
  • Pablo Scodeller,
  • Sazid Hussain,
  • Jinmyoung Joo,
  • Ester Kwon,
  • Gary B. Braun,
  • Tarmo Mölder,
  • Zhi-Gang She,
  • Venkata Ramana Kotamraju,
  • Barbara Ranscht,
  • Stan Krajewski,
  • Tambet Teesalu,
  • Sangeeta Bhatia,
  • Michael J. Sailor,
  • Erkki Ruoslahti

DOI
https://doi.org/10.1038/ncomms11980
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 11

Abstract

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Accurate treatment of traumatic brain injuries, a leading cause of neurological disability and death in young people, is hampered by poor accumulation of drugs in the brain. Here, the authors describe a tetrapeptide that can efficiently target brain injuries and deliver therapeutic or diagnostic payload.