Re-evaluation of the Fijianolide/Laulimalide Chemotype Suggests an Alternate Mechanism of Action for C‑15/C-20 Analogs

• Joseph D. Morris,
• Leila Takahashi-Ruiz,
• Lauren N. Persi,
• Jonathan C. Summers,
• Erin P. McCauley,
• Peter Y. W. Chan,
• Gabriella Amberchan,
• Itzel Lizama-Chamu,
• David A. Coppage,
• Phillip Crews,
• April L. Risinger,
• Tyler A. Johnson

Affiliations

Joseph D. Morris

Department of Natural Sciences, Dominican University of California, San Rafael, California, United States

Leila Takahashi-Ruiz

Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States

Lauren N. Persi

Department of Natural Sciences, Dominican University of California, San Rafael, California, United States

Jonathan C. Summers

Department of Natural Sciences, Dominican University of California, San Rafael, California, United States

Erin P. McCauley

Department of Chemistry & Biochemistry, University of California, Santa Cruz, California, United States

Peter Y. W. Chan

Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States

Gabriella Amberchan

Department of Chemistry & Biochemistry, University of California, Santa Cruz, California, United States

Itzel Lizama-Chamu

Department of Chemistry & Biochemistry, University of California, Santa Cruz, California, United States

David A. Coppage

Department of Chemistry & Biochemistry, University of California, Santa Cruz, California, United States

Phillip Crews

Department of Chemistry & Biochemistry, University of California, Santa Cruz, California, United States

April L. Risinger

Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States

Tyler A. Johnson

Department of Natural Sciences, Dominican University of California, San Rafael, California, United States