Communications Biology (Jul 2021)

FIP200 restricts RNA virus infection by facilitating RIG-I activation

  • Lingyan Wang,
  • Kun Song,
  • Wenzhuo Hao,
  • Yakun Wu,
  • Girish Patil,
  • Fang Hua,
  • Yiwen Sun,
  • Chaoqun Huang,
  • Jerry Ritchey,
  • Clinton Jones,
  • Lin Liu,
  • Jun-Lin Guan,
  • Shitao Li

DOI
https://doi.org/10.1038/s42003-021-02450-1
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 15

Abstract

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Lingyan Wang et al. report that the autophagy-associated protein FIP200 interacts with the RNA sensor RIG-I to trigger activation of the type I interferon pathway.