Manifest/Non-Manifest Drug Release Patterns from Polysaccharide Based Hydrogels—Case Study on Cyclodextrin—κ Carrageenan Crosslinked Hydrogels
Elena Simona Băcăiță,
Cătălina Anișoara Peptu,
Corina-Lenuta Savin (Logigan),
Marian Luțcanu,
Maricel Agop
Affiliations
Elena Simona Băcăiță
Department of Physics, Faculty of Machine Manufacturing and Industrial Management, “Gheorghe Asachi” Technical University of Iasi, Bd. Prof. Dr. Docent Dimitrie Mangeron 73, 700050 Iasi, Romania
Cătălina Anișoara Peptu
Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental Protection, “Gheorghe Asachi” Technical University of Iasi, 71, Prof. Dr. Docent Dimitrie Mangeron Street, 700050 Iasi, Romania
Corina-Lenuta Savin (Logigan)
Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental Protection, “Gheorghe Asachi” Technical University of Iasi, 71, Prof. Dr. Docent Dimitrie Mangeron Street, 700050 Iasi, Romania
Marian Luțcanu
Materials Science Department, Faculty of Materials Science and Engineering, “Gheorghe Asachi” Technical University of Iasi, 71, Prof. Dr. Docent Dimitrie Mangeron Street, 700050 Iasi, Romania
Maricel Agop
Department of Physics, Faculty of Machine Manufacturing and Industrial Management, “Gheorghe Asachi” Technical University of Iasi, Bd. Prof. Dr. Docent Dimitrie Mangeron 73, 700050 Iasi, Romania
The aim of this study is to offer a comprehensive view on drug release from hydrogel, from both an experimental and a theoretical point of view. Aiming to benefit cyclodextrins’ properties (not irritant; stable; able to modify the physical, chemical and biological properties of active compounds; accessible at low prices) and those of carrageenan polysaccharide (antitumor, immunomodulatory, antihyperlipidemic, anticoagulant, biocompatibility, biodegradability), original hydrogel films based on beta cyclodextrin and kappa carrageenan using epichlorohydrin as crosslinking agent were prepared and characterized from morphological and physical/chemical points of view. The results (morphology, the swelling degree, and the loading/release capacity) proved their potential as carriers for different types of drugs. Further, a new theoretical model, from a multifractal paradigm of motion, was proposed for the drug release from hydrogel films, starting from the fundaments of its evolution at a microscopic level, and aiming to obtain information on system evolution, at both the spatial and temporal scales, inapproachable by quantitative measurements.
