The Effect of Artificial Sweetener "Cipla" on Liver Function in Diabetic Male Rats

Abstract

Objectives: Sucralose is an artificial sweetener of sucrose, which is 600 times sweeter than sugar and produces low calories. Cipla is a commercial sweetener, which has sucralose and other various constituents. The present study evaluated the effects of Cipla on some biochemical factors of rats. Materials and Methods: The study was done on 24 male rats, which was randomly distributed to 4 groups of healthy control, diabetics control, treatment healthy, and diabetics treatment. Healthy and diabetic control groups were fed with a base diet. Healthy and diabetics treatment groups received sucralose through gavage 15 mg/kg daily for a month. Then, streptozotocin was administered intra-peritoneally (65 mg/kg one dose) to induce diabetes. At the end of the study, albumin, bilirubin, total protein, alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP) of the serum were evaluated and the results were analyzed by SPSS 22. Results: The results indicated that the total proteins of the serum, albumin, and bilirubin, ALT, AST, and ALP were not different statistically in different groups (P>0.05). Conclusions: In general, it was found that Cipla as a sweetener has not any side effects and has no negative effects on the liver function of the rat.

Keywords

• cipla
• sucralose
• serum biochemical parameters
• rat
• liver function