Vaginal microbiota in bacterial vaginosis. Aspects of diagnosis and therapy

Abstract

Bacterial vaginosis is a polymicrobial clinical syndrome characterized by the replacement of physiological Lactobacillus species with a spectrum of other microorganisms, mostly anaerobic. Numerous studies showed that key components of the vaginal microbiota in BV are Gardnerella vaginalis and Atopobium vaginae. A. vaginae are hard-to-culture bacteria whose involvement in BV has been described recently with the help of molecular methods. The article demonstrates that A. vaginae and G. vaginalis are responsible for the formation of biofilms on the vaginal epithelium. BV has a high recurrence rate, the main causes of which are presumably the resistance of BV-associated bacteria to antimicrobial agents and low susceptibility of biofilms to antibiotics.

Keywords

• микробиота влагалища
• бактериальный вагиноз
• gardnerella vaginalis
• atopobium vaginae
• биопленки
• диагностика
• терапия
• vaginal microbiota
• bacterial vaginosis
• gardnerella vaginalis
• atopobium vaginae
• biofilms
• diagnosis
• therapy