Investigating the association of exon variant rs1800470 of TGF-β1 gene with the risk of stroke using a meta-analysis approach

Abstract

Abstract Ischemic stroke is a type of stroke in which blood vessel blockage prevents blood supply to the brain. Transforming growth factor beta 1 (TGF-β1) is involved in the pathophysiology of several inflammatory diseases, including ischemic stroke. This study aimed to examine the relationship between rs1800470 (T869C) genetic variation in TGF-β1 gene and the risk of stroke in a meta-analysis approach. In a systematic review, we evaluated trustworthy databases and ultimately included nine eligible studies involving a total of 13,609 participants in our meta-analysis. The strength of association of rs1800470 variation with stroke risk evaluated using the odds ratio and 95% confidence interval. Stratified assessment was also performed according to ethnicity, type of stroke, and genotyping methods. Our data demonstrated substantial correlation between rs1800470 variation and elevated risk of stroke in overall analysis. Also, significant correlations were observed after ethnicity-based stratified analysis and genotyping methods. TGFβ1-rs1800470 could be regarded as a molecular biomarker for identifying at-risk individuals.

Keywords

• Ischemic stroke
• Genetic polymorphism
• TGF-β1
• Meta-analysis