Jurnal Penyakit Dalam Indonesia (Jun 2022)

Atherogenic Index Of Plasma is Correlated With Prolonged Length of Stay in COVID-19 Patients with Type 2 Diabetes Mellitus in RSUP Sanglah Denpasar

  • I Gede Gita Sastrawan,
  • Putu Satyakumara Upadhana,
  • Putu Novi Handayani,
  • Tika Rizki Nur Laela,
  • Kadek Aprilia Sukma Dewi,
  • I Nyoman Bayu Andika Wiguna,
  • Komang Andjani Putri,
  • Komang Adya Data Agrasidi,
  • Cindy Gracia Trisina,
  • Putu Sudarmika,
  • I Made Siswadi Semadi,
  • I Ketut Agus Somia

DOI
https://doi.org/10.7454/jpdi.v9i2.784
Journal volume & issue
Vol. 9, no. 2
pp. 108 – 113

Abstract

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Introduction. Atherogenic index of plasma (AIP) is a logarithmic calculation of the ratio of triglycerides to HDL cholesterol as a marker of lipid profile abnormalities. In COVID-19 patients with comorbid type 2 diabetes mellitus (T2DM), higher AIP tend to worsen the patient conditions. This study aims to assess the correlation between AIP and length of stay (LOS) in COVID-19 patients with T2DM. Methods. An analytical observational study with a cross-sectional approach was conducted among COVID-19 patients with comorbid T2DM. Data were collected from online medical records of confirmed COVID-19 patients with comorbid T2DM who were treated at Sanglah Hospital Denpasar during the period August 1-December 31, 2021. Patients who were <18 years old and did not have lipid profile data during treatment, were excluded from this study. Results. There were 83 data samples that met the study criteria. The median age of the patients was 64 (23- 91) years, the majority were male (59%; n=49), and 30 patients died during treatment (36.1%). The median LOS for all patients was 10 (1-26) days. Patients with prolonged LOS (≥10 days) had higher triglyceride levels (171.8 vs. 120 mg/dL; p<0.001) and AIP values (0.442 vs. 0.286; p=0.02). There was a strong relationship between AIP and LOS values in COVID-19 patients with T2DM (r=0.632; p<0.001). The AIP value can well-discriminated in prolonged LOS conditions (AUC=0.883; 95%CI 0.792-0.974) with the optimal cut-off value of 0.3045 (sensitivity 75.9% and specificity 83.3%). Conclusion. AIP is correlated with prolonged LOS in COVID-19 patients with T2DM. Holistic management of COVID-19 patients with T2DM is urgently needed, including lipid profile control.

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