Factors associated with poor discharge status in patients with status epilepticus at Khon Kaen hospital

Abstract

Piyawan Chiewthanakul,1 Parinya Noppaklao,2 Kittisak Sawanyawisuth,3,4 Somsak Tiamkao3,5 1Department of Medicine, Khon Kaen Hospital, Khon Kaen, Thailand; 2Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; 3Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; 4Research Center in Back, Neck, Other Joint Pain and Human Performance (BNOJPH), Khon Kaen University, Khon Kaen, Thailand; 5Integrated Epilepsy Research Group, Khon Kaen University, Khon Kaen, Thailand Background: Status epilepticus (SE) is a serious neurological condition and has high a mortality rate. Data on importance of factors associated with poor outcomes in Asian or Thai populations are limited.Methods: Adult patients diagnosed as SE at Khon Kaen hospital, Thailand from October 1, 2010 to September 30, 2012 were enrolled. Patients were categorized as good or poor outcomes at discharge. Good outcomes were defined by improvement at discharge and absence of neurological deficits, while poor outcomes were defined by: not being improved at discharge; being discharged against advice; death; or presence of a neurological deficit. Clinical factors were compared between both groups.Results: During the study period, there were 211 patients diagnosed as SE. Of those, 130 patients were male (61.61%). The mean age of all patients was 53.28 years. Acute stroke was the most common cause of SE in 33 patients (15.64%). At discharge, there were 91 patients (43.13%) who had poor outcomes. Only initial plasma glucose levels were significantly associated with poor outcomes with an adjusted odds ratio of 1.012 (95% confidence interval of 1.003 and 1.021). Conclusion: Initial plasma glucose is associated with poor discharge status in patients with SE. Keywords: hyperglycemia, outcomes, prognosis, risk factors