Molecules (Aug 2019)

Terpene Glycosides from <i>Sanguisorba officinalis</i> and Their Anti-Inflammatory Effects

  • Da-Le Guo,
  • Jin-Feng Chen,
  • Lu Tan,
  • Meng-Ying Jin,
  • Feng Ju,
  • Zhi-Xing Cao,
  • Fang Deng,
  • Li-Na Wang,
  • Yu-Cheng Gu,
  • Yun Deng

DOI
https://doi.org/10.3390/molecules24162906
Journal volume & issue
Vol. 24, no. 16
p. 2906

Abstract

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Two new terpene glycosides (1−2) along with two known analogs (3−4) were obtained from the root of Sanguisorba officinalis, which is a common traditional Chinese medicine (TCM). Their structures were elucidated by nuclear magnetic resonance (NMR), electrospray ionization high resolution mass spectrometry (HRESIMS), and a hydrolysis reaction, as well as comparison of these data with the literature data. Compounds 1−4 exhibited anti-inflammatory properties in vitro by attenuating the production of inflammatory mediators, such as nitric oxide (NO) as well as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). An anti-inflammatory assay based on the zebrafish experimental platform indicated that compound 1 had good anti-inflammatory activity in vivo by not only regulating the distribution, but also by reducing the amount of the macrophages of the zebrafish exposed to copper sulfate.

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