Antibacterial efficiency enhancement of gentamicin sulfate encapsulated CuS nanoparticles

Abstract

The use of engineered semiconductor nanomaterials to address multi-drug resistance in bacteria has gained attention. In this study, an environmentally friendly cost-effective biological approach to synthesize copper sulfide nanoparticles (CuS-NPs) is reported. The CuS-NPs and the antibiotic Gentamicin Sulfate (GS) at the concentration of 40 μg/mL exhibit significant synergistic inhibition against several human pathogens (E. coli, Salmonella typhi, Klebsiella pneumoniae, Staphylococcus aureus, and Bacillus subtilis). The effective release of antibiotic and less frequent administration are therapeutic advantages. The drug entrapment and loading capacity of synthesized CuS nanoparticles (CuS-NP) were recorded as 61% and 39%, respectively. Additionally, a promising activity of the mycosynthesized CuS-NP is an increased cytotoxicity against MDA-MB-231 breast cancer cell line, as indicated by the estimated IC50 value.

Keywords

• gentamicin sulfate
• cus nanoparticles
• myconanotechnology
• biosynthesis
• cytotoxicity