Frontiers in Cardiovascular Medicine (Sep 2022)

Case report: Cytokine therapy and an intracoronary autologous bone marrow-derived cell infusion with Impella support in a patient with dilated cardiomyopathy and a severely reduced ejection fraction

  • Russell Charles Hall,
  • Rohini Ramaseshan,
  • Rohini Ramaseshan,
  • Alice Reid,
  • Daniel A. Jones,
  • Daniel A. Jones,
  • Anthony Mathur,
  • Anthony Mathur

DOI
https://doi.org/10.3389/fcvm.2022.1002508
Journal volume & issue
Vol. 9

Abstract

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IntroductionThis is the first reported case of a patient with dilated cardiomyopathy (DCM) and severely impaired left ventricular function to receive a combined treatment of granulocyte colony-stimulating factor therapy and an intracoronary delivery of autologous bone marrow-derived mononuclear cells with percutaneous circulatory assistance (the Impella CP device; Abiomed, Danvers, MA).Main symptoms and outcomeThree months post-treatment, the gentleman in his early 70s demonstrated an improvement in left ventricular ejection fraction (13–17%) and a reduction in New York Heart Association class from III to class I. There was also an improvement in his 6-minute walk test (147–357 meters), N-terminal pro-brain natriuretic peptide level (14,099–7,129 ng/l) and quality of life scores. There were no safety concerns during the treatment or follow-up.ConclusionThis case report suggests combined cell and cytokine therapy with adjunctive circulatory support could be a safe and promising treatment for patients with DCM and severely reduced ejection fraction.

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