THE ROLE OF ROS1 GENE IN DEVELOPMENT OF STROKE

Abstract

Aim. To study the relation of mononucleotide polymorphism G?C (rs619203) of ROS1 gene with the risk of ischemic and hemorrhagic stroke development.Material and methods. Totally 152 patients studied (92 males, 60 females) with acute brain circulation disorder (stroke), of those 124 with ischemic stroke, and 28 with hemorrhagic, and 475 healthy people (320 males, 155 females) of controls. All patients underwent standard neurological, clinical and instrumental investigation in SCC FMBA (Krasnoyarskcity) and molecular-genetic investigation of DNA in SRI of Therapy and Prevention Medicine of SD RAMS (Novosibirskcity). Statistics included standard algorithm of statistical procedures.Results. The results of the study showed statistical predominance of prevalent genotype GG of ROS1 gene in ischemic stroke patients, comparing to control group.Conclusion. Homozygous genotype of GG gene of ROS1 is a risk factor for ischemic stroke.

Keywords

• gene ros1
• ischemic stroke
• hemorrhagic stroke