Instant diagnosis of gastroscopic biopsy via deep-learned single-shot femtosecond stimulated Raman histology

Zhijie Liu; Wei Su; Jianpeng Ao; Min Wang; Qiuli Jiang; Jie He; Hua Gao; Shu Lei; Jinshan Nie; Xuefeng Yan; Xiaojing Guo; Pinghong Zhou; Hao Hu; Minbiao Ji

doi:10.1038/s41467-022-31339-8

Nature Communications (Jul 2022)

Instant diagnosis of gastroscopic biopsy via deep-learned single-shot femtosecond stimulated Raman histology

Zhijie Liu,
Wei Su,
Jianpeng Ao,
Min Wang,
Qiuli Jiang,
Jie He,
Hua Gao,
Shu Lei,
Jinshan Nie,
Xuefeng Yan,
Xiaojing Guo,
Pinghong Zhou,
Hao Hu,
Minbiao Ji

Affiliations

Zhijie Liu: State Key Laboratory of Surface Physics and Department of Physics, Human Phenome Institute, Academy for Engineering and Technology, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), School of Life Sciences, Yiwu Research Institute, Fudan University
Wei Su: Endoscopy Center and Endoscopy Research Institute, Shanghai Collaborative Innovation Center of Endoscopy, Zhongshan Hospital, Fudan University
Jianpeng Ao: State Key Laboratory of Surface Physics and Department of Physics, Human Phenome Institute, Academy for Engineering and Technology, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), School of Life Sciences, Yiwu Research Institute, Fudan University
Min Wang: Department of Gastroenterology, Shanghai Children Hospital, Shanghai Jiaotong University
Qiuli Jiang: Department of Pathology, Endoscopic Center, Zhongshan Hospital (Xiamen Branch), Fudan University
Jie He: Department of Pathology, Endoscopic Center, Zhongshan Hospital (Xiamen Branch), Fudan University
Hua Gao: Department of Pathology, Endoscopic Center, Zhongshan Hospital (Xiamen Branch), Fudan University
Shu Lei: Department of Gastroenterology, Wuhan No. 1 Hospital
Jinshan Nie: Department of Gastroenterology, the 1st People’s Hospital of Taicang, Soochow University
Xuefeng Yan: Department of Gastroenterology, Shangrao Municipal Hospital
Xiaojing Guo: Department of Health Statistics, Faculty of Health Service, Naval Medical University
Pinghong Zhou: Endoscopy Center and Endoscopy Research Institute, Shanghai Collaborative Innovation Center of Endoscopy, Zhongshan Hospital, Fudan University
Hao Hu: Endoscopy Center and Endoscopy Research Institute, Shanghai Collaborative Innovation Center of Endoscopy, Zhongshan Hospital, Fudan University
Minbiao Ji: State Key Laboratory of Surface Physics and Department of Physics, Human Phenome Institute, Academy for Engineering and Technology, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), School of Life Sciences, Yiwu Research Institute, Fudan University

DOI: https://doi.org/10.1038/s41467-022-31339-8
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

Read online

Diagnosis of gastric cancer currently requires gastroscopic biopsy, which requires time and expertize to perform. Here, the authors demonstrate a femto-SRS imaging method which showed high accuracy in diagnosing gastric cancer without the need for pathologistbased diagnosis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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