Epigenetic profiles signify cell fate plasticity in unipotent spermatogonial stem and progenitor cells

Ying Liu; Eugenia G. Giannopoulou; Duancheng Wen; Ilaria Falciatori; Olivier Elemento; C. David Allis; Shahin Rafii; Marco Seandel

doi:10.1038/ncomms11275

Nature Communications (Apr 2016)

Epigenetic profiles signify cell fate plasticity in unipotent spermatogonial stem and progenitor cells

Ying Liu,
Eugenia G. Giannopoulou,
Duancheng Wen,
Ilaria Falciatori,
Olivier Elemento,
C. David Allis,
Shahin Rafii,
Marco Seandel

Affiliations

Ying Liu: Department of Medicine, Division of Regenerative Medicine, Ansary Stem Cell Institute, Weill Cornell Medical College
Eugenia G. Giannopoulou: Biological Sciences Department, New York City College of Technology, City University of New York
Duancheng Wen: Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College
Ilaria Falciatori: Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge
Olivier Elemento: HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medical College
C. David Allis: Chromatin Biology and Epigenetics, The Rockefeller University
Shahin Rafii: Department of Medicine, Division of Regenerative Medicine, Ansary Stem Cell Institute, Weill Cornell Medical College
Marco Seandel: Department of Surgery, Weill Cornell Medical College

DOI: https://doi.org/10.1038/ncomms11275
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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Spermatogonial stem cells (SSCs) spontaneously convert to multipotent adult spermatogonial-derived stem cells (MASCs). Here, the authors reveal the dynamics of bivalent histone H3-lysine4 and -lysine27 methylation signatures at somatic gene promoters in SSCs and ESC-like promoter chromatin states in MASCs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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