Frontiers in Cellular Neuroscience (Oct 2019)
Transcranial Current Stimulation Alters the Expression of Immune-Mediating Genes
- Monika Rabenstein,
- Marcus Unverricht-Yeboah,
- Meike Hedwig Keuters,
- Meike Hedwig Keuters,
- Meike Hedwig Keuters,
- Anton Pikhovych,
- Anton Pikhovych,
- Joerg Hucklenbroich,
- Joerg Hucklenbroich,
- Sabine Ulrike Vay,
- Stefan Blaschke,
- Stefan Blaschke,
- Stefan Blaschke,
- Anne Ladwig,
- Anne Ladwig,
- Helene Luise Walter,
- Magdalena Beiderbeck,
- Gereon Rudolf Fink,
- Gereon Rudolf Fink,
- Michael Schroeter,
- Michael Schroeter,
- Michael Schroeter,
- Ralf Kriehuber,
- Maria Adele Rueger,
- Maria Adele Rueger,
- Maria Adele Rueger
Affiliations
- Monika Rabenstein
- Department of Neurology, University Hospital of Cologne, Cologne, Germany
- Marcus Unverricht-Yeboah
- Radiation Biology Unit, Department of Safety and Radiation Protection, Research Centre Jülich, Jülich, Germany
- Meike Hedwig Keuters
- Department of Neurology, University Hospital of Cologne, Cologne, Germany
- Meike Hedwig Keuters
- Max Planck Institute for Metabolism Research, Cologne, Germany
- Meike Hedwig Keuters
- A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
- Anton Pikhovych
- Department of Neurology, University Hospital of Cologne, Cologne, Germany
- Anton Pikhovych
- Max Planck Institute for Metabolism Research, Cologne, Germany
- Joerg Hucklenbroich
- Department of Neurology, University Hospital of Cologne, Cologne, Germany
- Joerg Hucklenbroich
- Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Centre Jülich, Jülich, Germany
- Sabine Ulrike Vay
- Department of Neurology, University Hospital of Cologne, Cologne, Germany
- Stefan Blaschke
- Department of Neurology, University Hospital of Cologne, Cologne, Germany
- Stefan Blaschke
- Max Planck Institute for Metabolism Research, Cologne, Germany
- Stefan Blaschke
- Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Centre Jülich, Jülich, Germany
- Anne Ladwig
- Department of Neurology, University Hospital of Cologne, Cologne, Germany
- Anne Ladwig
- Max Planck Institute for Metabolism Research, Cologne, Germany
- Helene Luise Walter
- Department of Neurology, University Hospital of Cologne, Cologne, Germany
- Magdalena Beiderbeck
- Department of Neurology, University Hospital of Cologne, Cologne, Germany
- Gereon Rudolf Fink
- Department of Neurology, University Hospital of Cologne, Cologne, Germany
- Gereon Rudolf Fink
- Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Centre Jülich, Jülich, Germany
- Michael Schroeter
- Department of Neurology, University Hospital of Cologne, Cologne, Germany
- Michael Schroeter
- Max Planck Institute for Metabolism Research, Cologne, Germany
- Michael Schroeter
- Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Centre Jülich, Jülich, Germany
- Ralf Kriehuber
- Radiation Biology Unit, Department of Safety and Radiation Protection, Research Centre Jülich, Jülich, Germany
- Maria Adele Rueger
- Department of Neurology, University Hospital of Cologne, Cologne, Germany
- Maria Adele Rueger
- Max Planck Institute for Metabolism Research, Cologne, Germany
- Maria Adele Rueger
- Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Centre Jülich, Jülich, Germany
- DOI
- https://doi.org/10.3389/fncel.2019.00461
- Journal volume & issue
-
Vol. 13
Abstract
Despite its extensive use in clinical studies, the molecular mechanisms underlying the effects of transcranial direct current stimulation (tDCS) remain to be elucidated. We previously described subacute effects of tDCS on immune- and stem cells in the rat brain. To investigate the more immediate effects of tDCS regulating those cellular responses, we treated rats with a single session of either anodal or cathodal tDCS, and analyzed the gene expression by microarray; sham-stimulated rats served as control. Anodal tDCS increased expression of several genes coding for the major histocompatibility complex I (MHC I), while cathodal tDCS increased the expression of the immunoregulatory protein osteopontin (OPN). We confirmed the effects of gene upregulation by immunohistochemistry at the protein level. Thus, our data show a novel mechanism for the actions of tDCS on immune- and inflammatory processes, providing a target for future therapeutic studies.
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