Nature Communications (May 2017)

Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain

  • Bede Portz,
  • Feiyue Lu,
  • Eric B. Gibbs,
  • Joshua E. Mayfield,
  • M. Rachel Mehaffey,
  • Yan Jessie Zhang,
  • Jennifer S. Brodbelt,
  • Scott A. Showalter,
  • David S. Gilmour

DOI
https://doi.org/10.1038/ncomms15231
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

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The C-terminal domain (CTD) of RNA polymerase II is composed of a series of heptad repeats that exhibit some degree of sequence variation and that are subject to extensive phosphorylation. Here the authors provide evidence that local structural variations within the CTD are functionally important.