Emerging Infectious Diseases (Sep 2017)

Evaluation of 5 Commercially Available Zika Virus Immunoassays

  • David Safronetz,
  • Angela Sloan,
  • Derek R. Stein,
  • Emelissa Mendoza,
  • Nicole Barairo,
  • Charlene Ranadheera,
  • Leanne Scharikow,
  • Kimberly Holloway,
  • Alyssia Robinson,
  • Maya Traykova-Andonova,
  • Kai Makowski,
  • Kristina Dimitrova,
  • Elizabeth Giles,
  • Joanne Hiebert,
  • Rhonda Mogk,
  • Sharla Beddome,
  • Michael Drebot

DOI
https://doi.org/10.3201/eid2309.162043
Journal volume & issue
Vol. 23, no. 9
pp. 1577 – 1580

Abstract

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Because of the global spread of Zika virus, accurate and high-throughput diagnostic immunoassays are needed. We compared the sensitivity and specificity of 5 commercially available Zika virus serologic assays to the recommended protocol of Zika virus IgM-capture ELISA and plaque-reduction neutralization tests. Most commercial immunoassays showed low sensitivity, which can be increased.

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